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Medication language     Source https://www.rxlist.com/envarsus-drug.htm
LASTREVIEWED 08.12.2016

Brand Name Envarsus XR
Generic Name Tacrolimus


Manufacturer Rottendorf Pharma GmbH 59320 Ennigerloh North Rhine-Westphalia Germany. Manufactured for: Veloxis Pharmaceuticals, Inc. 499 Thornall Street, 3rd floor, Edison, New Jersey 08837, United States
    Pharmacotherapeutic group     Chemical name     Description     Pharmacokinetics     Clinical Pharmacology     Indications     ContraIndications     Warnings     Precautions     Side effects     Dosage and administration     Overdosage     Drug interactions     Patient Information     How Supplied     Storage conditions And Handling

Description

ENVARSUS XR, a calcineurin-inhibitor immunosuppressant, is available for oral administration as extended-release tablets containing the equivalent of 0.75 mg, 1 mg, or 4 mg of anhydrous tacrolimus USP.Inactive ingredients include hypromellose USP, lactose monohydrate NF, polyethylene glycol NF, poloxamer NF, magnesium stearate NF, tartaric acid NF, butylated hydroxytoluene NF, and dimethicone NF.
Tacrolimus is the active ingredient in ENVARSUS XR. Tacrolimus is a macrolide immunosuppressant produced by Streptomyces tsukubaensis.Chemically, tacrolimus is designated as [3S-[3R*[E(1S*,3S*,4S*)], 4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26ahexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclo-hexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, monohydrate.
The chemical structure of tacrolimus is:

ENVARSUS XR® (tacrolimus extended-release tablets), Structural Formula Illustration

Tacrolimus has an empirical formula of C44H69NO12•H2O and a formula weight of 822.03.Tacrolimus appears as white crystals or crystalline powder.It is practically insoluble in water, freely soluble in ethanol, and very soluble in methanol and chloroform.


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Analogs

MarkLanguageBrand NameGeneric NamePharmacotherapeutic groupRelease forms
ENGLISH (english)Astagraf XLtacrolimusCalcineurin-inhibitor immunosuppressantTablets
ENGLISH (english)PrograftacrolimusMacrolide immunosuppressant. T-lymphocyte inhibitorTablets, Liquid, Injection
ENGLISH (english)ProtopictacrolimusMacrolide immunosuppressant. T-lymphocyte inhibitorOintment
3 Medications
         
Medication Analogs Generic Name medicines of the ATC group

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