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Medication language     Source https://www.rxlist.com/entresto-drug.htm
LASTREVIEWED 30.10.2017

Brand Name Entresto
Generic Name sacubitril and valsartan


Manufacturer Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936.Revised: Aug 2015
Distributer Novartis Pharmaceuticals Corporation East Hanover, New Jersey 07936.Revised: Aug 2015
    Pharmacotherapeutic group     Chemical name     Description     Pharmacokinetics     Clinical Pharmacology     Indications     ContraIndications     Warnings     Precautions     Side effects     Dosage and administration     Overdosage     Drug interactions     Patient Information     How Supplied     Storage conditions And Handling

Description

ENTRESTO (sacubitril and valsartan) is a combination of a neprilysin inhibitor and an angiotensin II receptor blocker.
ENTRESTO contains a complex comprised of anionic forms of sacubitril and valsartan, sodium cations, and water molecules in the molar ratio of 1:1:3:2.5, respectively.Following oral administration, the complex dissociates into sacubitril (which is further metabolized to LBQ657) and valsartan.
ENTRESTO is available as film-coated tablets for oral administration, containing 24 mg of sacubitril and 26 mg of valsartan;49 mg of sacubitril and 51 mg of valsartan;and 97 mg of sacubitril and 103 mg of valsartan.The tablet inactive ingredients are microcrystalline cellulose, low-substituted hydroxypropylcellulose, crospovidone, magnesium stearate (vegetable origin), talc, and colloidal silicon dioxide.The film-coat inactive ingredients are hypromellose, titanium dioxide (E 171), Macrogol 4000, talc, and iron oxide red (E 172).The film-coat for the 24 mg of sacubitril and 26 mg of valsartan tablet and the 97 mg of sacubitril and 103 mg of valsartan tablet also contains iron oxide black (E 172).The film-coat for the 49 mg of sacubitril and 51 mg of valsartan tablet contains iron oxide yellow (E 172).


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